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Chimerism Studies

Test performed by: LabPLUS - Dept. Diagnostic Genetics - Molecular Haematology


Specimen Collection

Note: All samples should be forwarded to LabPlus at room temperature within 24hours.

CPD4 mL CPD Blood (Preferred)
CPD4 mL CPD Bone Marrow (Preferred)
EDTA4 mL EDTA Bone Marrow
Micro-EDTA0.5 mL Paediatric Micro-EDTA Blood
Micro-EDTA0.5 mL Paediatric Micro-EDTA Bone Marrow
Turnaround Time: Within 2 weeks, 4 days
Diagnostic Use and Interpretation

This test uses DNA profiling to determine the contribution of donor or recipient DNA within a blood or bone marrow sample (although conceivably any sample from which DNA may be extracted could be used in this test, including blood enriched for Lymphoid (CD3+) cells (see link below)) after a patient has undergone a bone marrow transplant.  The DNA profiling is performed using a panel of usually 16 different loci. A percentage contribution is calculated for each loci and the average is taken to give the percentage donor and/or recipient content.

DNA Chimerism studies will be required following a sex-matched bone marrow transplant. Please submit a second CPD tube with the Donor Storage specimen, if this service is clinically indicated.
If a bone marrow transplant is sex-mismatched, FISH chimerism studies should be considered instead.

See also:

T-cell separation

Contact Information

To contact the Molecular Haematology team please call:

Auckland City Hospital   (09) 307 4949
Lablink   ext 22000
Prof. Peter Browett (Haematologist)     ext 9090-86281
Nikhil Ghallayan (Section Leader)   ext 22006
Molecular Haematology Lab   ext 22005

For more inforamtion about the Molecular Haematology service at LabPLUS:

Molecular Haematology information page

Test performed by: LabPLUS - Dept. Diagnostic Genetics - Cytogenetics


This test is performed using Fluorescent in situ hybridization (FISH).  For specimen collection details please refer to:

Chromosome Analysis -Bone Marrow Test Page

Information on Chimerism Studies:

Last updated at 11:48:27 18/03/2021