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Factor V Leiden Mutation Analysis
Short Description : Factor V mutation analysis
Also known as : [Factor Five],[Factor V Mutation Analysis],[FV]


DNA/RNA
Test performed by: LabPLUS - Dept. Diagnostic Genetics - Molecular Haematology


Specimen Collection

Note: All samples should be forwarded to LabPlus at room temperature within 24hours.


CPD4 mL CPD Blood (Preferred)
EDTA4 mL EDTA Blood
Turnaround Time: Within 2 weeks, 4 days
Diagnostic Use and Interpretation

This test detects the Factor V Leiden mutation in the Factor V gene. The resultidentifies a heritable cause for APC resistance and thus can indicate an increased risk of thrombosis.

See also:

Prothrombin mutation analysis


Contact Information

To contact the Molecular Haematology team please call:

Auckland City Hospital   (09) 307 4949
Lablink   ext 22000
Prof. Peter Browett (Haematologist)     ext 9090-86281
Nikhil Ghallayan (Section Leader)   ext 22006
Molecular Haematology Lab   ext 22005

For more inforamtion about the Molecular Haematology service at LabPLUS:

Molecular Haematology information page




Information on Factor V Leiden Mutation:

A mutation in the factor V gene which changes arginine 506 to a glutamine does not affect the coagulation properties of factor V but renders the protein resistant to protein C degradation.  This mutation leads to Protein C resistance and is hence a thrombosis risk factor.

References:
Bertina RM et al. Nature, 1993, 369:64-67.


Last updated at 11:48:27 18/03/2021