DISCLAIMER: This link was displayed at 00:58:31 21/04/2024 and expires on 26/04/2024 if printed.
Go to http://testguide.adhb.govt.nz/EGuide/ for more information.
Prothrombin Variant (G20210A) Analysis
Short Description : Prothrombin mutation analysis
Also known as : [Factor II Mutation Analysis],[Prothrombin Mutation Analysis],[Prothrombin Variant Analysis]
DNA/RNA
Test performed by: LabPLUS - Dept. Diagnostic Genetics - Molecular Haematology
Specimen Collection
Note:
All samples should be forwarded to LabPlus at room temperature within 24hours.
4 mL CPD Blood (Preferred)
4 mL EDTA Blood
Turnaround Time: Within 2 weeks, 4 days
Diagnostic Use and Interpretation
This test detects a common variant in the Prothrombin gene. Results can be used to establish a heritable cause for an increased risk of thrombosis.
See also:
Factor V Leiden mutation analysis
Diagnostic Use and Interpretation
Contact Information
To contact the Molecular Haematology team please call:
For more information about the Molecular Haematology service at LabPLUS:
Molecular Haematology information page
Information on the Prothrombin Variation (G20210A):
A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Up to 18% of patients with a family history of venous thrombosis have been reported to be carriers of this variant as compared to approximately 1% in the general population. Heterozygous patients have a 3 - 4 fold increased risk of thrombosis. The prothrombin 20210A allele is detected by PCR of a 169bp product of the 3'-untranslated region of the gene using a downstream mutagenic primer which introduces a Hind III site in the presence of the A allele.
References:
Poort SR et al. Blood 88: 3698-3703; 1966
Last updated at 15:36:59 07/03/2024