This test may be vetted by a pathologist.
The clinical information for the test must be clearly written on the request form. If clinical information is not provided, or does not provide sufficient justification for the test, the test may be declined.
Declined tests :
If a test is declined, the specimen will be held for a reasonable period (usually 3 weeks but dependant on the stability of the sample). Medical practitioners seeking approval for a declined test should email the on-call Chemical Pathologist ( chemicalpathologist@adhb.govt.nz ) , giving the patient's name and NHI number and the clinical justification for the test. If unable to email, call the on-call Chemical Pathologist via Lablink (09-3078995) and identify yourself as a doctor.
Note: Please note the new reference ranges for IGF-1 as of 28/10/16.
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Units: ng/ml (ug/L)
The reference intervals above apply to IGF-1 measured using the Diasorin Liaison analyser. The intervals represent the 2.5th and 97.5th centiles and are derived from Bidlingmaier et al., J Clin Endocrinol Metab 99 (5): 1712-1721, 2014.
Uncertainty of Measurement: 15%
Conversion factor :
ng/mL = ug/L
ug/L x 0.13 = nmol/L
nmol/L x 7.7 = ug/L
For an IGF-1 SD score calculator , click on the link below or contact chemicalpathologist@adhb.govt.nz
Download: Spreadsheet: - IGF-1 SD score calculator Liaison version 5.xlsx
Performed once a week
Principle : Sandwich type immunoassay
Assay : Diasorin
Analyser : Diasorin Liaison
Low IGF-I
values are consistent with growth hormone deficiency or resistance, but are also seen in malnutrition. The diagnosis of growth hormone deficiency may require confirmation with a GH stimulation test.
High IGF-I
values are consistent with acromegaly, and simple measurement of growth hormone and IGF-I is an adequate screen for this disorder.
Requests for IGF-1 tests may be vetted. Criteria for approval of IGF-1 tests:
- Tests requested by endocrinologists or paediatricians will be approved
- Approved for investigation or monitoring of short stature, hypopituitarism or acromegaly - please state this clearly on the request form
-
NOT approved for "wellness testing" or chronic fatigue.
Emails to chemicalpathologist@adhb.govt.nz will receive priority attention from the on-call chemical pathologist.
If the query concerns a specific patient please include the NHI number in your email.
If email is not a suitable option, please contact the on-call chemical pathologist via Lablink (Auckland City Hospital ext. 22000 or 09-3078995).
Individual chemical pathologists may be contacted but will not be available at all times.
After-hours : contact Lablink (Auckland City Hospital ext. 22000 or 09-3078995) or hospital operator for on duty staff after hours.
Dr Samarina Musaad (Clinical Lead) : SamarinaM@adhb.govt.nz ext. 22402
Dr Cam Kyle: CampbellK@adhb.govt.nz ext 22052
Dr Weldon Chiu: WeldonC@adhb.govt.nz ext. 23427
Dr Campbell Heron: CHeron@adhb.govt.nz ext. 23427
Dr Sakunthala Jayasinghe: Sakunthala@adhb.govt.nz ext. 23427
Stability:
| Sample Type | Stability |
| Whole blood | 3 hours at room temperature |
| Serum |
24 hours at 4oC 12 months frozen |
NOTE : Heparin plasma is unsuitable for IGF-1 by this method