The quoted therapeutic range is for trough concentrations; specimens should be collected shortly before administering the next dose of the drug.
PST / SST samples are NOT suitable for this test.
Sample stability:
-
2 days at 20-25 o C
-
7 days at 2-8 o C
-
4 weeks at -20 o C
Units: umol/L
|
Therapeutic Range (trough) : 16 - 40 |
Uncertainty of Measurement: 6%
Principle: Immunoturbidometric assay
Reagents: Roche TDM Carbamazepine Gen. 4
Analyser: Cobas c502
Monitoring:
Carbamazepine is an anti-epileptic agent displaying anticonvulsive and psychotropic activity.
Determination of serum levels can be useful as a means of establishing the optimum dose, especially where carbamazepine is being used for combined therapy.
Blood counts and liver function tests should be performed before commencing treatment. Blood counts should be repeated at weekly intervals for the first month of treatment and then at monthly intervals.
Liver function tests should also be performed at regular intervals - see Hepatotoxic Drug Reactions .
Emails to chemicalpathologist@adhb.govt.nz will receive priority attention from the on-call chemical pathologist.
If the query concerns a specific patient please include the NHI number in your email.
If email is not a suitable option, please contact the on-call chemical pathologist via Lablink (Auckland City Hospital ext. 22000 or 09-3078995).
Individual chemical pathologists may be contacted but will not be available at all times.
After-hours : contact Lablink (Auckland City Hospital ext. 22000 or 09-3078995) or hospital operator for on duty staff after hours.
Dr Samarina Musaad (Clinical Lead) : SamarinaM@adhb.govt.nz ext. 22402
Dr Cam Kyle: CampbellK@adhb.govt.nz ext 22052
Dr Weldon Chiu: WeldonC@adhb.govt.nz ext. 23427
Dr Campbell Heron: CHeron@adhb.govt.nz ext. 23427
Dr Sakunthala Jayasinghe: Sakunthala@adhb.govt.nz ext. 23427