If >24hrs, please refrigerate and transport specimens.
If samples will take longer than 5 days to arrive, please send frozen.
Sample stability:
-
24 hours at 15-25 o C
-
5 days at 2-8 o C
-
6 months at -20 o C
Units: ug/L.
Reference ranges:
|
Females
|
Age (y)
|
Reference Interval
|
|
|
<1
|
430 - 3000
|
|
|
1 to 10
|
280 - 830
|
|
|
10 to <14
|
140 - 1200
|
|
|
14 to <18
|
40 - 460
|
|
|
18 to <25
|
20 - 110
|
|
|
25 to <35
|
20 - 85
|
|
|
35+ (premenopausal)
|
15 - 60
|
|
|
35+ (postmenopausal)
|
20 - 115
|
|
Males
|
<1
|
430 - 3000
|
|
|
1 to <12
|
240 - 820
|
|
|
12 to <17
|
220 - 1600
|
|
|
17 to <18
18 to <20
|
80 - 480
60-220
|
|
|
21 to <25
|
35 - 140
|
|
|
25+
|
20 - 85
|
Uncertainty of Measurement: 10%
Note: Supplementary biotin may cause falsely low results .
Principle : Electrochemiluminescence Immunoassay
Reagents: Roche Elecsys Total P1NP
Analyser: Cobas e801
P1NP (procollagen-1 N-terminal peptide) is a peptide formed during type 1 collagen synthesis, and its plasma concentration is an index of the rate of bone turnover .
Plasma P1NP is increased in states of high bone turnover such as normal growth, healing fractures, Paget's disease, osteoporosis, hyperparathyroidism, and hyperthyroidism.
It can be used to monitor therapy in Paget's disease and osteoporosis.
Its use as a predictor of future bone loss in osteoporosis is not yet well established.
The assay measures total P1NP (intact P1NP plus a smaller peptide), which is partially cleared by the kidney; hence P1NP levels increase in renal failure.
P1NP is not a marker of liver fibrosis: see P3NP.
Note: Supplementary biotin may cause falsely low results .
The chemical pathology team can be reached via email: chemicalpathologist@adhb.govt.nz or via Lablink (09) 307 4949 ext 22000 or 09-3078995
Emails will receive priority attention from the on-call chemical pathologist. Include the patients NHI.
After-hours: contact Lablink (Auckland City Hospital ext. 22000 or 09-3078995) or hospital operator for on duty staff after hours .
- Dr Samarina Musaad (Clinical Lead) : SamarinaM@adhb.govt.nz ext. 22402
- Dr Cam Kyle : CampbellK@adhb.govt.nz ext 22052
- Dr Weldon Chiu : WeldonC@adhb.govt.nz ext. 23427
- Dr Campbell Heron : CHeron@adhb.govt.nz ext. 23427
- Dr Sakunthala Jayasinghe Saku.Jayasinghe@adhb.govt.nz
- Dr Owen Yi WenyiYi@adhb.govt.nz
Send at 2-8C if less than 5 days post collection.
If stored greater than 5 days post collection sample must be sent frozen.