If >24hrs, please refrigerate and transport specimens.
If samples will take longer than 5 days to arrive, please send frozen.
Sample stability:
-
24 hours at 15-25 o C
-
5 days at 2-8 o C
-
6 months at -20 o C
Units: ug/L.
Reference ranges:
|
Females
|
Age (y)
|
Reference Interval
|
|
|
<1
|
430 - 3000
|
|
|
1 to 10
|
280 - 830
|
|
|
10 to <14
|
140 - 1200
|
|
|
14 to <18
|
40 - 460
|
|
|
18 to <25
|
20 - 110
|
|
|
25 to <35
|
20 - 85
|
|
|
35+ (premenopausal)
|
15 - 60
|
|
|
35+ (postmenopausal)
|
20 - 115
|
|
Males
|
<1
|
430 - 3000
|
|
|
1 to <12
|
240 - 820
|
|
|
12 to <17
|
220 - 1600
|
|
|
17 to <18
18 to <20
|
80 - 480
60-220
|
|
|
21 to <25
|
35 - 140
|
|
|
25+
|
20 - 85
|
Uncertainty of Measurement: 10%
Note: Supplementary biotin may cause falsely low results .
Principle : Electrochemiluminescence Immunoassay
Reagents: Roche Elecsys Total P1NP
Analyser: Cobas e801
P1NP (procollagen-1 N-terminal peptide) is a peptide formed during type 1 collagen synthesis, and its plasma concentration is an index of the rate of bone turnover .
Plasma P1NP is increased in states of high bone turnover such as normal growth, healing fractures, Paget's disease, osteoporosis, hyperparathyroidism, and hyperthyroidism.
It can be used to monitor therapy in Paget's disease and osteoporosis.
Its use as a predictor of future bone loss in osteoporosis is not yet well established.
The assay measures total P1NP (intact P1NP plus a smaller peptide), which is partially cleared by the kidney; hence P1NP levels increase in renal failure.
P1NP is not a marker of liver fibrosis: see P3NP.
Note: Supplementary biotin may cause falsely low results .
Emails to chemicalpathologist@adhb.govt.nz will receive priority attention from the on-call chemical pathologist.
If the query concerns a specific patient please include the NHI number in your email.
If email is not a suitable option, please contact the on-call chemical pathologist via Lablink (Auckland City Hospital ext. 22000 or 09-3078995).
Individual chemical pathologists may be contacted but will not be available at all times.
After-hours : contact Lablink (Auckland City Hospital ext. 22000 or 09-3078995) or hospital operator for on duty staff after hours.
Dr Samarina Musaad (Clinical Lead) : SamarinaM@adhb.govt.nz ext. 22402
Dr Cam Kyle: CampbellK@adhb.govt.nz ext 22052
Dr Weldon Chiu: WeldonC@adhb.govt.nz ext. 23427
Dr Campbell Heron: CHeron@adhb.govt.nz ext. 23427
Dr Sakunthala Jayasinghe: Sakunthala@adhb.govt.nz ext. 23427
Send at 2-8C if less than 5 days post collection.
If stored greater than 5 days post collection sample must be sent frozen.