Sample stability:
-
3 days at 15-25 o C
-
3 days at 2-8 o C
-
6 months at -20 o C
Uncertainty of Measurement:
beta-2-Microglobulin 6%
| Age Range | Either Sex |
|---|---|
| < | 0.8 - 2.2 |
Beta-2-microglobulin is a low molecular weight protein found on the surface of most nucleated cells. It forms the light chain component of the histocompatability antigen. Beta-2-microglobulin is eliminated via the kidneys; following filtration through the glomeruli it is reabsorbed and catabolised by the proximal tubular cells.
Serum:
Multiple myeloma: An indicator of prognosis, and for monitoring disease progress. The serum concentration correlates with the tumour cell mass.
Elevated serum levels can also occur with rheumatoid artritis, systemic lupus erythematosus, and malignant lymphoma.
Renal failure: Beta-2-microglobulin is cleared by glomerular filtration and the serum concentration increases in parallel with serum creatinine in renal failure.
HIV: An indicator of prognosis and disease progression. A serum concentration > 4.0 mg/L is associated with increased progression to AIDS.
Urine:
Renal tubular function: Filtered beta-2-microglobulin is catabolised by the renal tubule; increased urinary concentrations are seen in renal tubular dysfunction, e.g. acute tubular necrosis, nephrotoxic drugs.
See beta-2 microglobulin, urine
References:
1 Tietz. Clinical guide to laboratory tests. 2nd edition 1990.
2 Mayo Medical Laboratories Test Catalog 2003.
3 Schardijn, GHC and Status van Eps, LW (1987). beta-2 microglobulin: its significance in the evaluation of renal function. Kidney Intl. 32, 635-641.
4 Shea, PH et al. (1981). Prediction of glomerular filtration rate by serum creatinine and beta-2 microglobulin. Nephron 29, 30-35.
5 Crisp, AJ et al. (1983). Beta-2 microglobulin levels reflect activity in rheumatoid arthritis. J Rheumatol. 10, 954-956.
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