.
|
Age (Yrs) |
IgG1 g/L |
IgG2 g/L |
IgG3 g/L |
IgG4 g/L |
|
0-2 |
1.9-8.4 |
0.2-3.0 |
0.2-0.9 |
0.01-0.8 |
|
2-4 |
3.2-9.5 |
0.4-2.3 |
0.2-0.7 |
0.01-0.5 |
|
4-6 |
3.1-9.5 |
0.6-3.5 |
0.1-1.2 |
0.02-1.1 |
|
6-8 |
2.9-9.2 |
0.4-3.8 |
0.2-0.9 |
0.01-1.0 |
|
8-10 |
4.3-10.2 |
0.7-4.3 |
0.1-0.9 |
0.02-0.9 |
|
10-12 |
4.2-10.6 |
0.8-3.6 |
0.2-1.7 |
0.02-1.2 |
|
12-14 |
3.4-11.5 |
1.0-4.6 |
0.3-1.3 |
0.04-1.4 |
|
14-18 |
3.2-8.6 |
0.6-5.0 |
0.2-2.0 |
0.11-1.6 |
|
Adult |
3.8-9.3 |
2.4-7.0 |
0.2-1.8 |
0.04-0.9 |
Uncertainty of measurement:
6% 6% 6% 4%
Undetected antigen excess is a rare event but cannot be excluded. Falsely low results can occasionally occur. If these results do not agree with other clinical or laboratory findings, or if the samples is from a patient that has previously demonstrated antigen excess, please contact the laboratory for repeat testing. Results should always be interpreted in conjunction with other laboratory tests and clinical evidence; any anomalies should be discussed with the testing laboratory.
.
In normal adults, IgG constitutes approximately 75% of total serum immunoglobulin. Within the IgG class, the usual order of concentration of the 4 subclasses is IgG1>IgG2>IgG3>IgG4, but the actual concentration of each may vary markedly between individuals.
The four IgG subclasses show considerable differences in their properties, including ability to fix complement, to bind to macrophages and to pass through the placenta. Abnormal levels of one or more subclass may be associated with certain conditions, including anaphylaxis, autoimmune and gut diseases as well as hypo- and hyper gammaglobulinaemia (ref 1). In particular, reduced production of IgG2 in children may be associated with recurrent infections (ref 2).
References
1 Shakib, F & Stanworth, D R (1980). Human IgG subclasses in health and disease (Part II). La Ricerca Clin, Lab. 10, 561-580.
2 Shackleford, P G, Polmar, S H et al. (1986). Spectrum of IgG2 subclass deficiency in children with recurrent infections: Prospective Study. J. Pediatr. 108, 647-653.
3 Hamilton, R H (1987), Human IgG subclass measurements in the clinical laboratory. Clin. Chem. 33, 1707-1725.
4 Schur, P H (1987), IgG subclasses - a review. Annals of Allergy 58, 89-99.
For further information contact the laboratory (09) 307 4949 ext 22000 or:
Associate Professor Rohan Ameratunga , Immunopathologist: Locator 93-5724
Or the LabPLUS Immunology Team