Specimen Collection

2.7 mL Citrate Blood

or

1.8 mL Citrate Blood

or

1 mL Paediatric Micro-citrate Blood

• Tube must be adequately filled.

Reference Intervals

Uncertainty of Measurement : 8%

Units: g/L

Age Range	Either Sex
All	1.5 - 4.0 [1]

[1]

• Antenatal: 2.0 - 6.5 g/L
• Newborn : near normal adult levels.

Turnaround Time: Within 2 hours
Diagnostic Use and Interpretation

Increased

As part of acute phase response. e.g. acute and chronic inflammation, liver disease, pregnancy, compensated intravascular coagulation, nephrotic syndrome.

Decreased

In congenital hypofibrinogenaemia (rare), DIC, advanced liver disease, lytic therapy, L-asparaginase therapy. Acquired dysfibrinogenaemia occurs mainly in association with liver and renal disease. Bleeding is rarely a problem. Typically, thrombin clotting time is long and /or fibrinogen is low.

Result interpretation can be difficult in the presence of dysfibrinogenaemia, high FDP and high dose heparin, when fibrinogen can appear (falsely) low.

NOTE: In consumptive processes serial fibrinogen levels are of more use than single point assays.

See

Thrombin Clotting Time

Contact Information

For further information contact the Haematology laboratory (Ext 22067) or:

Dr Nicola Eaddy	Ext 22005
Dr Peter Bradbeer	Ext 22062
Dr Anna Ruskova	Ext 22137
Dr Nikhil Rabade	Ext 22071

Last updated at 10:31:53 18/09/2024