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MethylMalonic Acid - Plasma/Serum
Short Description : MMA - Serum/plasma


Blood
Test performed by: LabPLUS Support Services transport this to a 3rd party for testing


Specimen Collection

Specimen Reception

Canterbury Health Laboratories

Christchurch Hospital

Corner of Hagley and Tuams Street

Christchurch

Refer to link below for more information:

Methylmalonic acid


Heparin

5 mL Adult Heparin Plasma

Heparin

1 mL Paediatric Heparin Plasma

Plain

1 mL Paediatric Plain Blood

Plain

4 mL Adult Plain Serum

SST

3.5 mL Adult SST Blood

PST

5 mL Adult PST Blood
Turnaround Time: Within 2 weeks
Diagnostic Use and Interpretation

Serum/plasma MMA is increased in vitamin B12 deficiency.

A level less than 0.3 umol/L rules out B12 deficiency with high probability.

A raised MMA level is not specific for B12 deficiency. Other causes of elevated MMA include renal impairment , small bowel bacterial overgrowth , and unexplained raised MMA levels in the presence of normal B12 status are not uncommon.

Ref : Carmel, R. (2011). "Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II." Am J Clin Nutr 94 (1): 18.


Contact Information

Emails to chemicalpathologist@adhb.govt.nz will receive priority attention from the on-call chemical pathologist.

If the query concerns a specific patient please include the NHI number in your email.

If email is not a suitable option, please contact the on-call chemical pathologist via Lablink (Auckland City Hospital ext. 22000 or 09-3078995).

Individual chemical pathologists may be contacted but will not be available at all times.

After-hours : contact Lablink (Auckland City Hospital ext. 22000 or 09-3078995) or hospital operator for on duty staff after hours.


Dr Samarina Musaad (Clinical Lead) : SamarinaM@adhb.govt.nz ext. 22402

Dr Cam Kyle: CampbellK@adhb.govt.nz ext 22052

Dr Weldon Chiu: WeldonC@adhb.govt.nz ext. 23427

Dr Campbell Heron: CHeron@adhb.govt.nz ext. 23427

Dr Sakunthala Jayasinghe: Sakunthala@adhb.govt.nz ext. 23427



Specimen Transport Instructions for Referring Laboratories

Specimen Collection

Patient Specimen Blood 5 mL Plain (T15), Heparinised or EDTA OK.
Paediatric Specimen Blood 1 mL Plain, Heparinised or EDTA OK.
Sample Delivery to Lab Ambient

Instructions for Referral to CHLabs

Aliquot Instructions 2.0 mL plasma or serum 0.3 mL minimum
Aliquot Transport to CHL 4 C or frozen



Last updated at 15:26:00 06/01/2025