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MethylMalonic Acid - Plasma/Serum
Short Description : MMA - Serum/plasma


Blood
Test performed by: LabPLUS Support Services transport this to a 3rd party for testing


Specimen Collection

Specimen Reception

Canterbury Health Laboratories

Christchurch Hospital

Corner of Hagley and Tuams Street

Christchurch

Refer to link below for more information:

Methylmalonic acid


Heparin

5 mL Adult Heparin Plasma

Heparin

1 mL Paediatric Heparin Plasma

Plain

1 mL Paediatric Plain Blood

Plain

4 mL Adult Plain Serum

SST

3.5 mL Adult SST Blood

PST

5 mL Adult PST Blood
Turnaround Time: Within 2 weeks
Diagnostic Use and Interpretation

Serum/plasma MMA is increased in vitamin B12 deficiency.

A level less than 0.3 umol/L rules out B12 deficiency with high probability.

A raised MMA level is not specific for B12 deficiency. Other causes of elevated MMA include renal impairment , small bowel bacterial overgrowth , and unexplained raised MMA levels in the presence of normal B12 status are not uncommon.

Ref : Carmel, R. (2011). "Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II." Am J Clin Nutr 94 (1): 18.


Contact Information

The chemical pathology team can be reached via email: chemicalpathologist@adhb.govt.nz or via Lablink (09) 307 4949 ext 22000 or 09-3078995

Emails will receive priority attention from the on-call chemical pathologist. Include the patients NHI.

After-hours: contact Lablink (Auckland City Hospital ext. 22000 or 09-3078995) or hospital operator for on duty staff after hours .



Specimen Transport Instructions for Referring Laboratories

Specimen Collection

Patient Specimen Blood 5 mL Plain (T15), Heparinised or EDTA OK.
Paediatric Specimen Blood 1 mL Plain, Heparinised or EDTA OK.
Sample Delivery to Lab Ambient

Instructions for Referral to CHLabs

Aliquot Instructions 2.0 mL plasma or serum 0.3 mL minimum
Aliquot Transport to CHL 4 C or frozen



Last updated at 11:42:03 16/01/2026