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IgH-Bcl2 Transcript Detection by PCR - t(14;18)
Short Description : IgH-Bcl2 transcript detection by PCR
Also known as : [14;18],[non-Hodgkin's lymphoma],[t(14;18)]
DNA/RNA
Test performed by: LabPLUS - Dept. Diagnostic Genetics - Molecular Haematology
Specimen Collection
4 mL CPD Blood (Preferred)
2 mL CPD Bone Marrow (Preferred)
4 mL EDTA Blood
2 mL EDTA Bone Marrow
Turnaround Time: Within 2 weeks, 4 days
Diagnostic Use and Interpretation
This test detects the presence of an IgH/bcl-2 rearrangement resulting from a t(14;18) chromosomal translocation associated with follicular and non-Hodgkin's lymphomas. In t(14;18) there is no fusion protein, instead promoter exchange from IgH to bcl-2 stimulates the expression of BCL2 (BCL2 is an inhibitor of apoptosis).
Contact Information
To contact the Molecular Haematology team please call:
For more information about the Molecular Haematology service at LabPLUS:
Molecular Haematology information page
FISH
Test performed by: LabPLUS - Dept. Diagnostic Genetics - Cytogenetics
A FISH (fluorescent in situ hydridisation) based assay is also available for this test.
Refer to Molecular Cytogenetics Probe List
Information on the IgH-Bcl2 Translocation:
Last updated at 15:36:59 07/03/2024