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Go to http://testguide.adhb.govt.nz/EGuide/ for more information.

Specimen Collection

Note: All samples should be forwarded to LabPlus at room temperature within 24hours.

4 mL CPD Blood (Preferred)
4 mL CPD Bone Marrow (Preferred)
4 mL EDTA Blood
4 mL EDTA Bone Marrow
0.5 mL Paediatric Micro-EDTA Blood
0.5 mL Paediatric Micro-EDTA Bone Marrow
Turnaround Time: Within 2 weeks, 4 days
Diagnostic Use and Interpretation

This test uses DNA profiling to determine the contribution of donor or recipient DNA within a blood or bone marrow sample (although conceivably any sample from which DNA may be extracted could be used in this test, including blood enriched for Lymphoid (CD3+) cells (see link below)) after a patient has undergone a bone marrow transplant.  The DNA profiling is performed using a panel of usually 16 different loci. A percentage contribution is calculated for each loci and the average is taken to give the percentage donor and/or recipient content.

DNA Chimerism studies will be required following a sex-matched bone marrow transplant. Please submit a second CPD tube with the Donor Storage specimen, if this service is clinically indicated.
If a bone marrow transplant is sex-mismatched, FISH chimerism studies should be considered instead.

See also:

T-cell separation

Contact Information

To contact the Molecular Haematology team please call:

Auckland City Hospital	(09) 307 4949
Lablink	ext 22000
Prof. Peter Browett (Haematologist)	ext 9090-86281
Dr. Imogen Caldwell (Haematologist)	ext 22006
Nikhil Ghallayan (Section Leader)	ext 22005
Molecular Haematology Office	ext 22005

For more information about the Molecular Haematology service at LabPLUS:

Molecular Haematology information page

Last updated at 15:36:59 07/03/2024