Note: The test methodology used in this lab has been developed for haematological neoplasms and is not suitable for tumours such as melanoma. All samples should be forwarded to LabPlus at room temperature within 24hours.
4 mL CPD Blood (Preferred) 2 mL CPD Bone Marrow (Preferred) 4 mL EDTA Blood 2 mL EDTA Bone Marrow Sterile Container Tissue Turnaround Time: Within 4 weeks Diagnostic Use and Interpretation Contact Information
To contact the Molecular Haematology team please call:
Auckland City Hospital (09) 307 4949 Lablink ext 22000 Prof. Peter Browett (Haematologist) ext 9090-86281 Nikhil Ghallayan (Section Leader) ext 22006 Molecular Haematology Lab ext 22005
For more inforamtion about the Molecular Haematology service at LabPLUS:
Molecular Haematology information page
The proto-oncogene c-Kit encodes a transmembrane tyrosine kinase receptor which is expressed on cells such as haematopoietic stem cells and mast cells. A relatively common D816V mutation in exon 17 has been identified in patients with mastocytosis but additional activating mutations have now also been identified in other proliferative disorders. Mutations within exons 8 to 13 and exon 17 have been associated with gastrointestinal stromal tumours, haematopoietic neoplasms and mastocytosis.
References : Nagata H et al. PNAS (1995), 92, 10560-10564. Lengyel et al Current Molecular Medicine 7(1):77-84, 2007. Paschka et al Journal of Clinical Oncology 24:3904-3911, 2006.