| Age Range | Either Sex |
|---|---|
| All | >= 16[1] |
Total IgG measuring range: 3.3 - 270 mg/L
Uncertainty of measurement: 20%
Test performed on a batch basis (minimum of eleven specimens required).
Turnaround time 2 - 3 weeks.
This assay is designed to measure IgG /IgG2 subclass antibody responses to pneumococcal vaccines incorporating 23 polysaccharides isolated form Streptococcus Pneumoniae . These polysaccharides represent approximately 80% of the commonly encountered virulent serotypes.
The response in 30% of subjects to vaccination with S.pneumoniae is attributed to C-polysaccharide (CPS) antibodies and not too specific anti-PCP IgG/anti-PCP IgG2. These CPS antibodies confer limited protection against pneumococcal infection, consequently CPS absorption has been incorporated in this assay.
Pneumococcal polysaccharide antigens elicit the production of mainly IgG/IgG2 antibodies, via a thymus independent response. Patients with repeated bacterial infections should be investigated for immunodeficiency and thus inability to respond to specific polysaccharide antigens.
A patient's specific antibody response may be elevated by the serological determination of their IgG/IgG2 anti-PCP antibody levels pre- and post-vaccination using this quantitative enzyme immunoassay.
References
1. Binding Site Bidazyme Anti-PCP IgG2 Enyme Immunoassay Kit package insert.
2. Dr Rohan Ameratunga
For further information contact the laboratory, (09) 307 4949 ext 22103 or:
Associate Professor Rohan Ameratunga
, Immunopathologist: Locator
93-5724,