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Memory and Naive B-Cell Markers
Also known as : [B cells assay],[Naive B cells]


Blood
Test performed by: LabPLUS Cell Markers


For all queries, including specimen requirements and results, contact the Cell Marker section of the Haematology laboratory ( Ext22061 or 22075),

or via Lablink   22000 or (09) 307-8995 or 0800 522 758 .


Specimen Collection
Heparin4 mL Heparin Blood

Dark green top Heparin tubes are required ,

light green top PST Heparin tubes(containing gel) are NOT suitable.

 

or

 


Micro-heparin1 mL Paediatric Micro-heparin Blood

Dark green top Heparin tubes are required ,

light green top PST Heparin tubes(containing gel) are NOT suitable.

For samples sent to LabPlus from outside the Auckland region:
  • Must be pre-arranged with cell marker staff.
  • Sample collection as above , transport at room temperature.
  • Sample age limit for testing to be completed is 24 hours.


Reference Intervals

3 subsets of B-cells have been identified with the following phenotype:

  1. Naive B-cells , CD19+CD27-IgD+
  2. Memory B-cells (unswitched), CD19+CD27+IgD+
  3. Memory B-cells (Switched), CD19+CD27+IgD-

Reference Range:

Naive B-cells 57.7 - 79.7 %
Memory B-cells (unswitched), 8.7 - 18.7 %
Memory B-cells (Switched) 5 - 21 %



Turnaround Time: Within 2 weeks
Diagnostic Use and Interpretation

Common Variable Immune Deficiency (CVID) is a heterogeneous group of immune deficient disease. The underlying immunological defect of this syndrome is unknown. CVID patients are characterised by low levels of immunoglobulins and normal to low B-lymphocyte levels.


Contact Information

For further information contact the Cell Markers laboratory  (Ext . 22061), or out of hours on-call: 021 753 059 , or

Dr Rohan Ameratunga , Immunologist: Locator 93-5724

or the Immunology Team



Last updated at 13:32:52 28/04/2013