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Maternal serum screen - 1st and 2nd trimester
Short Description : Maternal Serum Screening - 1st Trimester and Integrated/ Antenatal screening


Blood
Test performed by: LabPLUS Antenatal Down Screening


Specimen Collection

Separate serum within 4 hours of collection. Store and ship at 4 o C within 12 hours of collection. Otherwise freeze serum then send sample frozen. 


SST7 mL Adult SST Blood (Preferred)

Please send 2 X 3.5 mL SST tube


Plain8 mL Adult Plain Blood

Please send 2 X 4 mL plain tube


Reference Intervals

Reference intervals will be provided with the results.



Turnaround Time: Between 1 day and 3 days
Contact Information

Via Lablink (09) 307 4949 ext. 22000 or 0800 522 758 or coordinator (09) 307 4949 ext. 23124 or 021 884 621 

The scientist responsible for this test is Tamara Butler, email tamara@adhb.govt.nz


Result Details

First trimester screen is measurement of PAPP-A and freeB-hCG. Results are combined with Nuchal translucency to produce a risk that the pregnancy is affected by Down syndrome or a number of other conditions.

Second trimester screen is a measurement of AFP, free B-hCG, unconjugated estriol (UE 3 ) and Inhibin A to produce a risk factor that the pregnancy is affected by Down Syndrome or a number of other conditions.  NTD risk is calculated if the sample has been taken after 15 weeks of gestation.

Integrated screening is measurement of PAPP-A in the first trimester, measurement of AFP, unconjugated estriol, freeB -hCG, and Inhibin A in the second trimester, and integrating these results with Nuchal translucency to produce a risk that the pregnancy is affected by Down syndrome or a number of other conditions. This is not funded by NSU but is available at a cost of $190 + GST to the patient.

Results are given as the value compared to the population median value for that analyte at that gestational age (MoM, multiple of the median). Hence 1.0 MoM is on the median value, 2.0 MoM is high at twice the median value and 0.5 MoM low at half the median value.


Specimen Transport Instructions for Referring Laboratories

Separate serum within 4 hours of collection. Store and ship at 4 o C within 12 hours of collection. Otherwise freeze serum then send sample frozen. 

First trimester combined test is blood test plus Nuchal Translucency (NT). Blood must be taken between 9 weeks and 13 weeks 6 days gestation.

Second trimester blood test must be taken between 14 weeks and 20 weeks 6 days gestation.

Integrated test is blood tests in both the first and second trimesters plus Nuchal Translucency. The first trimester blood must be taken between 9 weeks and 13 weeks 6 days gestation and the second trimester blood between 14 weeks and 20 weeks 6 days gestation.

First and second trimester screens are paid for by the Ministry of Health National Screening Unit.  The patient is entitled to one or the other.  If a fully integrated screen, first trimester, NT plus second trimester is required there is a cost of $190 + GST.



Last updated at 08:58:04 13/10/2022