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IgH-Bcl2 Transcript Detection by PCR - t(14;18)
Short Description : IgH-Bcl2 transcript detection by PCR
Also known as : [14;18],[non-Hodgkin's lymphoma],[t(14;18)]


DNA/RNA
Test performed by: LabPLUS - Dept. Diagnostic Genetics - Molecular Haematology


Specimen Collection
CPD4 mL CPD Blood (Preferred)
CPD2 mL CPD Bone Marrow (Preferred)
EDTA4 mL EDTA Blood
EDTA2 mL EDTA Bone Marrow
Turnaround Time: Within 2 weeks, 4 days
Diagnostic Use and Interpretation

This test detects the presence of an IgH/bcl-2 rearrangement resulting from a t(14;18) chromosomal translocation associated with follicular and non-Hodgkin's lymphomas. In t(14;18) there is no fusion protein, instead promoter exchange from IgH to bcl-2 stimulates the expression of BCL2 (BCL2 is an inhibitor of apoptosis). 


Contact Information

To contact the Molecular Haematology team please call:

Auckland City Hospital   (09) 307 4949
Lablink   ext 22000
Prof. Peter Browett (Haematologist)     ext 9090-86281
Nikhil Ghallayan (Section Leader)   ext 22006
Molecular Haematology Lab   ext 22005

For more inforamtion about the Molecular Haematology service at LabPLUS:

Molecular Haematology information page



FISH
Test performed by: LabPLUS - Dept. Diagnostic Genetics - Cytogenetics


A FISH (fluorescent in situ hydridisation) based assay is also available for this test.

Refer to Molecular Cytogenetics Probe List




Information on the IgH-Bcl2 Translocation:


Last updated at 11:48:27 18/03/2021