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Circulating Immune Complexes
Short Description : CBA

Test performed by: LabPLUS VIM Proteins

Specimen Collection

The serum may be stored at 2-8 o C for up to 7 days prior to testing.  For prolonged storage, the serum should be aliquoted and stored at -20 o C or below.

SST3.5 mL SST Serum (Preferred)
Plain4 mL Plain Serum
Reference Intervals

The concentration is expressed as ug/ml heat aggregated gammaglobulin (HAG) equivalent.

Uncertainty of measurement: 10% 

(based on less than 20 data points)

Units: ug/mL
Age RangeEither Sex
All< 4.4
Age RangeEither Sex
All>= 10.8
Age RangeEither Sex
All4.4 - 10.7

Turnaround Time: Between 1 week and 3 weeks
Assay Method

Solid phase immunoenzymatic assay (ELISA).   C1q containing immune complexes bind to monoclonal anti-C1q antibody attached to microwell strips using the AUTOSTAT II C1q Containing Circulating Immune Complexes kit

Diagnostic Use and Interpretation

Circulating Immune Complexes (CIC) is present often in patients with Rheumatoid Arthritis (RA) and systemic Lupus Erythematosus (SLE) especially where vasculitis is implicated.  Levels of CIC have been reported to show correlation with disease activity in that higher levels are reported during active phases of the disease.  No single procedure appears to detect all types of CICs, however the use of C1q and C3d fragments to detect CIC appear to detect clinically relevant events.

In serum sickness, which is the prototype Immune Complex Disease, positive C1q CIC results are obtained.  This assay detects immune complexes containing both C1q and IqG. 

Contact Information

For further information contact the laboratory (09) 307 4949 ext 22000 or:

Associate Professor Rohan Ameratunga , Immunopathologist: Locator 93-5724

Or the LabPLUS Immunology Team

Specimen Transport Instructions for Referring Laboratories

Samples stored at 2-8 o C can be tested within 7 days of collection.  For longer storage samples must be frozen and transported at -20 o C

Last updated at 12:31:38 05/10/2021