NOTE: RNA is highly unstable and specimens degrade rapidly. For optimum results samples should be sent in CPD tubes at room temperature and be received by this lab within 24 hours of collection. Although LabPlus operates 24 hours a day, 7 days a week, the Molecular Haematology section only operates 9-5, Mon-Fri (excluding public holidays). Samples arriving on a Friday afternoon or a Saturday or Sunday may not get processed until the following Monday. Such delays can significantly compromise the quality of the sample.
9 mL CPD Blood (Preferred) 2 mL CPD Bone Marrow (Preferred) 9 mL EDTA Blood 2 mL EDTA Bone Marrow Turnaround Time: Within 4 weeks Diagnostic Use and Interpretation
This test is specifically designed to detect aquired mutations in the BCR-ABL transcript. Ph+ patients may develop mutations in the BCR-ABL gene, in response to tyrosine kinase inhibitor treatment, that cause drug resistance. Some of these mutations are known to lack resistance to certain forms or doses of tyrosine kinase inhibitors so a detailed knowledge of the precise mutation in a given patient can be helpful when reassessing treatment.
BCR-ABL Analysis by Q-PCR
BCR-ABL Transcript Detection by RT-PCR
To contact the Molecular Haematology team please call:
Auckland City Hospital (09) 307 4949 Lablink ext 22000 Prof. Peter Browett (Haematologist) ext 9090-86281 Nikhil Ghallayan (Section Leader) ext 22006 Molecular Haematology Lab ext 22005
For more inforamtion about the Molecular Haematology service at LabPLUS:
Molecular Haematology information page