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BCR-ABL Tyrosine Kinase Sequencing
Also known as : [BCR-ABL Sequencing],[RT-PCR]

Test performed by: LabPLUS - Dept. Diagnostic Genetics - Molecular Haematology

Specimen Collection

NOTE: RNA is highly unstable and specimens degrade rapidly. For optimum results samples should be sent in CPD tubes at room temperature and be received by this lab within 24 hours of collection. Although LabPlus operates 24 hours a day, 7 days a week, the Molecular Haematology section only operates 9-5, Mon-Fri (excluding public holidays). Samples arriving on a Friday afternoon or a Saturday or Sunday may not get processed until the following Monday. Such delays can significantly compromise the quality of the sample. 

CPD9 mL CPD Blood (Preferred)
CPD2 mL CPD Bone Marrow (Preferred)
EDTA2 mL EDTA Bone Marrow
Turnaround Time: Within 4 weeks
Diagnostic Use and Interpretation

This test is specifically designed to detect aquired mutations in the BCR-ABL transcript. Ph+ patients may develop mutations in the BCR-ABL gene, in response to tyrosine kinase inhibitor treatment, that cause drug resistance. Some of these mutations are known to lack resistance to certain forms or doses of tyrosine kinase inhibitors so a detailed knowledge of the precise mutation in a given patient can be helpful when reassessing treatment.  

See also:

BCR-ABL Analysis by Q-PCR

BCR-ABL Transcript Detection by RT-PCR

Contact Information

To contact the Molecular Haematology team please call:

Auckland City Hospital   (09) 307 4949
Lablink   ext 22000
Prof. Peter Browett (Haematologist)     ext 9090-86281
Nikhil Ghallayan (Section Leader)   ext 22006
Molecular Haematology Lab   ext 22005

For more inforamtion about the Molecular Haematology service at LabPLUS:

Molecular Haematology information page

Information on ABL Tyrosine Kinase Sequencing:

Last updated at 11:48:27 18/03/2021