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Specimen Collection
2.7 mL Citrate Blood

or

1 mL Paediatric 2xCitrate Blood

or

1.8 mL 2xCitrate Blood

• Tube must be adequately filled.

Referral Laboratories:

Please separate the specimen and send minimum 1.0 ml platelet poor plasma to LabPlus frozen.

Reference Intervals

For paediatric reference range information, contact a paediatric Haematologist.

Uncertainty of Measurement:         12%

Units: %

Age Range	Either Sex
>= 1 y	70 - 120

Turnaround Time: Within 2 weeks
Diagnostic Use and Interpretation

• Test performed is a Functional Protein C assay.
• Protein C is a vitamin K dependent anticoagulant protein, synthesised in the liver. It is activated to APC by thrombin and it functions as an anticoagulant by inactivating activated factors V and VIII. Its activity is enhanced by its cofactor protein S.
• A low functional result should be confirmed on a repeat sample.

• Protein C deficiency may occur due to congenital homo/heterozygous protein C deficiency and may occur as an acquired deficiency due to vitamin K deficiency, oral anticoagulants, liver disease, and DIC.
  

  See: 

Protein C

Contact Information

For further information contact the Haematology laboratory (Ext 22067) or:

Dr Nicola Eaddy	Ext 22005
Dr Peter Bradbeer	Ext 22062
Dr Anna Ruskova	Ext 22137
Dr Nikhil Rabade	Ext 22071

Last updated at 13:09:28 11/09/2024