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Factor VIII/Factor IX
Short Description : Factor VIII/Factor 8 and Factor IX/Factor 9

Blood
Test performed by: LabPLUS Coagulation

Specimen Collection

Collection of samples for Factor VIII

Requests for Chromogenic FVIII must be referred through a Haematologist or Haemophilia Centre.

Citrated platelet poor plasma. Minimum volume 0.5 mL.


Citrate2.7 mL Adult Citrate Blood

or


2xCitrate1.8 mL 2xCitrate Blood

  • If the specimen is collected from outside Auckland Hospital: send  2x 1.5 ml plasma aliquot, frozen.


    • Reference Intervals

    Normal Reference Intervals:

     Factors VIII and IX 55 - 150%

    Factors Uncertainty of measurement
    VIII , IX, XI , XII               18%

    •  Paediatric reference intervals are age stratified and given on the result report



    Turnaround Time: Within 2 weeks

    Unless URGENT


    Diagnostic Use and Interpretation

    Factor assays are generally used to identify the cause of bleeding disorders. However, factors II, VII and VIII are included in the investigation of thrombosis.

    The Chromogenic FVIII is used in suspected mild haemophilia A and not usually required for management. Requests for Chromogenic FVIII must be referred through a Haematologist or Haemophilia Centre.

    See Bleeding History

    Limitations of procedure:

    Factor assays may be affected by sample activation or the presence of inhibitors.

    Interpretation:

    Coagulation factors may be reduced due to defective production (congenital or acquired defects), consumption (DIC), dilution (massive transfusion), destruction (specific inhibitors), and in the case of factors II, VII, IX, or X, vitamin K deficiency/warfarin ingestion.


    Contact Information

    For further information contact the Haematology laboratory (Ext 22067) or:

    Dr Nicola Eaddy                                    Ext 22005
    Dr Peter Bradbeer                                   Ext 22062  
    Dr Anna Ruskova                                   Ext 22137
    Dr Nikhil Rabade                                   Ext 22071



    Last updated at 13:09:28 11/09/2024