Measurable Residual Disease (MRD) by Flow Cytometry

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Measurable Residual Disease (MRD) by Flow Cytometry
Short Description : MRD by Flow Cytometry

Test performed by: LabPLUS Cell Markers

For all queries, including specimen requirements and results, contact the Cell Marker section of the Haematology laboratory ( Ext22061 or 22075),

or via Lablink 22000 or (09) 307-8995 or 0800 522 758 .

Routine service Monday to Friday
For weekdays prior to a public holiday samples should be received in the laboratory by 1500 to allow for testing.
Requests for urgent testing will be prioritized within working hours.
Requests for critical testing outside of these times is by arrangement, and must be approved by the laboratory haematologist on call. They can be contacted via the hospital operator.

For samples from other centres, please notify the Flow Cytometry laboratory by email at: flow@adhb.govt.nz . Please supply the courier tracking number.

Specimen Collection
For Collection and Transport protocols of specific MRD tests click on the following links:

Acute Myeloid leukaemia MRD (AML 19 protocol).
Acute Myeloid leukaemia MRD Assessment - Regional Guidelines .
B-Lymphoblastic leukaemia MRD (COG protocol).
Multiple Myeloma MRD (Euroflow protocol).

Other MRD tests:

Chronic lymphocytic leukaemia (CLL MRD)(ERIC protocol)

CLL MRD on peripheral blood:

- minimum 8ml peripheral blood in EDTA tubes

CLL MRD on bone marrow:

- 3-4ml of bone marrow in EDTA tubes. Add 2ml of bone marrow to each EDTA tube. First aspirate is required.

T-cell acute lymphoblastic leukaemia MRD (T-ALL MRD)

Day 8 peripheral blood testing:

- minimum 2ml peripheral blood in EDTA tube

MRD bone marrow time points:

- 3-4ml of bone marrow in EDTA tubes. Add 2ml of bone marrow to each EDTA tube. First aspirate is required.

Transport MRD samples at 4 ^o C without delay. Do not spin or freeze.

Turnaround Time: Within 5 days

Preliminary verbal results to a referring pathologist may be available within 36-hours of specimen receipt, Monday to Friday.

All results and morphology are reviewed by a Haematologist with an interpretive comment being an essential part of the final report.

Turnaround time is up to 5 working days however, depending on the complexity of the case and whether additional studies are required, the final report may take 7 working days.

Contact Information
For further information contact the Cell Marker section of the Haematology laboratory ( 09 3074949 Ext 22061 or 22075 ).
Out of hours laboratory on-call 1630 - 2400hrs on weeknights, 0800 - 2400hrs weekends and public holidays: 021 753 059.

Haematologist advice may also be obtained during working hours from:

Dr Anna Ruskova, Clinical Lead/Laboratory Haematologist:               Ext. 22137

Dr Louisa Stone, Laboratory Haematologist                                           Ext. 22062

Dr Nikhil Rabade, Laboratory Haematologist                                          Ext 22071

Dr Peter Bradbeer, Laboratory Haematologist                                         Ext. 22062

Dr Nicola Eaddy, Laboratory Haematologist                                          Ext. 22005

An on-call Laboratory Haematologist is able to be contacted via the hospital operator outside of normal working hours.

Last updated at 11:04:01 14/11/2024