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IgH-Bcl2 Transcript Detection by PCR - t(14;18)
Short Description : IgH-Bcl2 transcript detection by PCR
Also known as : [14;18],[non-Hodgkin's lymphoma],[t(14;18)]

DNA/RNA
Test performed by: LabPLUS - Dept. Diagnostic Genetics - Molecular Haematology

Specimen Collection

CPD

4 mL CPD Blood (Preferred)

CPD

2 mL CPD Bone Marrow (Preferred)

EDTA

4 mL EDTA Blood

EDTA

2 mL EDTA Bone Marrow
Turnaround Time: Within 2 weeks, 4 days
Diagnostic Use and Interpretation

This test detects the presence of an IgH/bcl-2 rearrangement resulting from a t(14;18) chromosomal translocation associated with follicular and non-Hodgkin's lymphomas. In t(14;18) there is no fusion protein, instead promoter exchange from IgH to bcl-2 stimulates the expression of BCL2 (BCL2 is an inhibitor of apoptosis).


Contact Information

To contact the Molecular Haematology team please call:

Auckland City Hospital (09) 307 4949
Lablink ext 22000
Prof. Peter Browett (Haematologist) ext 9090-86281
Dr. Imogen Caldwell (Haematologist) ext 22006
Nikhil Ghallayan (Section Leader) ext 22005
Molecular Haematology Office ext 22005

For more information about the Molecular Haematology service at LabPLUS:

Molecular Haematology information page


FISH
Test performed by: LabPLUS - Dept. Diagnostic Genetics - Cytogenetics


A FISH (fluorescent in situ hydridisation) based assay is also available for this test.

Refer to Molecular Cytogenetics Probe List


Information on the IgH-Bcl2 Translocation:


Last updated at 15:36:59 07/03/2024