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Specimen Collection

• Red cell reduced Glutathione enzyme is stable at 4 Degrees Celsius for 2-3 days.
• Any specimens transported overnight should be transported on wet ice.

4 mL EDTA Blood
5 mL Heparin Blood
Reference Intervals
Units: mmol/L red cells

Age Range	Either Sex
All	2.3 - 3.4[1]

[1] Coefficient of variation:       4.0% in normal range
Turnaround Time: Within 2 days

Test performed Monday to Friday, but must be received before noon on Friday.

Diagnostic Use and Interpretation

• Red cell reduced glutathione concentration should be determined in the investigation of non-spherocytic haemolytic anaemia.
• Deficiencies of enzymes in the GSH synthetic pathways are well documented
  although rare.  The deficiencies cause hereditary non-spherocytic haemolytic
  anaemia.  The enzymes involved are GSH-synthetase and glutamylcysteine
  synthetase.  In the presence of these enzyme deficiencies, the red cell glutathione
  evel is generally very low i.e less than 0.7mmol/L
• A moderate reduction in GSH has been reported in some forms by hereditary
  non-spherocytic haemolytic anaemia e.g G-6PD deficiency, glucosephosphate
  isomerase deficiency and with unstable haemoglobins
• Increased GSH levels occur in Pyrimidine-5-nucleotidase deficiency.

See:

Pyrimidine-5-nucleotidase

Contact Information

For further information contact the Special Haematology laboratory (Ext 22065) or:

Dr Anna Ruskova		Ext 22137
Dr Louisa Stone		Ext 22062
Dr Peter Bradbeer		Ext 22062

Last updated at 09:21:41 07/02/2023