Note: Bone marrow aspirate is the preferred specimen type for this assay. Peripheral blood should only be considered if bone marrow is unobtainable and there are known to be sufficient lymphoplasmocytic cells in circulation for analysis.
Recurrent activating mutations within MYD88 have been identified in
certain sub-types of B-cell lymphomas. The c.794T>C (L265P) mutation in exon 5 of the MYD88
gene is seen in >90% of patients with Waldenstrom's macroglobulinemia (IgM secreting
lymphoplasmacytic lymphoma) and non-IgM-secreting lymphoplasmacytic lymphoma (LPL) [N Eng
Med 2012;367:826-833]. MYD88 mutations have also been reported in up to 10-30% of other
lymphomas of B-cell origin such as; ABC-DLBCL, GCB-DLBCL, CLL and MALT lymphomas. The
c.794T>C mutation can be detected by allele specific PCR with a sensitivity of 0.1% using the
method of Varettoni et al. Blood 2013;121(13): 2522-2528.
To contact the Molecular Haematology team please call:
| Auckland City Hospital | (09) 307 4949 |
| Lablink | ext 22000 |
| Prof. Peter Browett (Haematologist) | ext 9090-86281 |
| Dr. Imogen Caldwell (Haematologist) | ext 22006 |
| Nikhil Ghallayan (Section Leader) | ext 22005 |
| Molecular Haematology Office | ext 22005 |
For more information about the Molecular Haematology service at LabPLUS: