Sample stability:
|
Serum
|
EDTA
|
Uncertainty of Measurement : 16% <1mg/L
4% at a level of 3mg/L
| Age Range | Either Sex |
|---|---|
| < 3 m | 1.1 - 2 |
| >= 3 m | 0.45 - 1 |
Principle: Immunoturbidometric assay
Assay: Roche CYSC2 kit
Analyser: Cobas c702
Cystatin C may be useful in the diagnosis and monitoring of renal disease.
Cystatin C is a small protein produced by all nucleated cells. The production rate is constant and is not significantly affected by gender, age and muscle mass. Cystatin C is almost freely filtered by the normal kidney, and nearly completely degraded by the proximal tubular cells. The plasma concentration of cystatin C is largely determined by the glomerular filtration rate (GFR). Non-GFR determinants include body fat percentage, thyroid diseases and use of corticosteroids.
Cystatin C may be superior to creatinine as a marker for GFR in some patient groups e.g. those with GFR between 60-79ml/min/1.73m2, children and people with abnormally low or high muscle mass.
Emails to chemicalpathologist@adhb.govt.nz will receive priority attention from the on-call chemical pathologist.
If the query concerns a specific patient please include the NHI number in your email.
If email is not a suitable option, please contact the on-call chemical pathologist via Lablink (Auckland City Hospital ext. 22000 or 09-3078995).
Individual chemical pathologists may be contacted but will not be available at all times.
After-hours : contact Lablink (Auckland City Hospital ext. 22000 or 09-3078995) or hospital operator for on duty staff after hours.
Dr Samarina Musaad (Clinical Lead) : SamarinaM@adhb.govt.nz ext. 22402
Dr Cam Kyle: CampbellK@adhb.govt.nz ext 22052
Dr Weldon Chiu: WeldonC@adhb.govt.nz ext. 23427
Dr Campbell Heron: CHeron@adhb.govt.nz ext. 23427