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C3 Nephritic Factor
Short Description : Nephritic factor

Blood
Test performed by: LabPLUS VIM Proteins


Specimen must be separated and frozen within 1 hour and sent frozen to the laboratory.

This test may be vetted by a pathologist.

The clinical information for the test must be clearly written on the request form. If clinical information is not provided, or does not provide sufficient justification for the test, the test may be declined.

Declined tests :

If a test is declined, the specimen will be held for a reasonable period (usually 3 weeks but dependant on the viability of the sample). Medical practitioners seeking approval for a declined test should email the LabPLUS Immunology Team , giving the patient's name and NHI number and the clinical justification for the test. If unable to email, call the on-call Immunologist via Lablink (09-3078995).

Test vetting policy

Specimen Collection
EDTA4 mL EDTA Plasma (Always Required)
Reference Intervals

Normal = Not Detected

Abnormal = Detected.



Turnaround Time: Between 1 week and 2 weeks
Diagnostic Use and Interpretation

C3 Nephritic Factor (Autoantibody) produces undue C3 consumption and is mostly associated with nephritis;

Mesangio capillary glomerulonephritis - MCGN

Post-streptococcal glomerulonephritis (PSGN) this can be transient IgG3 autoantibody or a persistent (life long) one.

Acquired partial lipodystrophy, CNF and C3 hypocomplementemia is associated with this syndrome.

Some patients with Systemic Lupus Erythematosus (SLE) may develop CNF.

Patients with C3 Nephritic Factor most often have markedly low plasma C3 levels.  However these patients do not suffer unduly from severe infections.

References

1  Complement; John Whicher, M.A, M.B; M.R.C. Path. Penzil Evans.

2    Dia Sorin C3 Complement Antiserum; Package Insert.

3    The Complement System, M.M. Frank.  Immunological Diseases, 4th Edition (1988) p. 203, 1335, 1365, 1809.


Contact Information

For further information contact the laboratory (09) 307 4949 ext 22000 or:

Associate Professor Rohan Ameratunga , Immunopathologist: Locator 93-5724

Or the LabPLUS Immunology Team



Last updated at 12:52:43 01/12/2021