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MuSk Antibodies

Blood
Test performed by: LabPLUS VIM Serology


This test may be vetted by a pathologist.

The clinical information for the test must be clearly written on the request form. If clinical information is not provided, or does not provide sufficient justification for the test, the test may be declined.

Declined tests :

If a test is declined, the specimen will be held for a reasonable period (usually 3 weeks but dependant on the viability of the sample). Medical practitioners seeking approval for a declined test should email the LabPLUS Immunology Team , giving the patient's name and NHI number and the clinical justification for the test. If unable to email, call the on-call Immunologist via Lablink (09-3078995).

Test vetting policy

In addition to this assay being a requested test, it will also be performed as a reflex test in the setting of a first-time AChRAb negative result. Patients reactive for AChRAb will not be tested for MuSK antibodies.

Specimen Collection
SST3.5 mL SST Serum (Preferred)
Plain4 mL Plain Serum
Reference Intervals

Uncertainty of measurement  20%


Units: mmol/L
Age RangeEither Sex
All< 0.05

Turnaround Time: Between 3 weeks and 4 weeks

Due to the testing protocols, this is a batched assay and urgent/one off testing is not available.


Assay Method

Current Methodology in use at LabPLUS for Neuronal antibodies

 

Test / Group                     Methodology                                          Manufacturer

 

NMDAR Ab                                    IFA (Transfected cells)                                       Euroimmun (Germany)

 

Limbic encephalitis

panel                                           IFA (Transfected cells)                                          Euroimmun (Germany)

 

Aquaporin-4 Ab                            IFA (Transfected cells)                                        Euroimmun (Germany)

                                 

Onconeuronal                          Line Immunoassay (LIA)                                        NOVA, USA (IFA) and LIA

antibody panel                         and IFA (Monkey cerebellum)                                  Euroimmun (Germany)  

 

AChRAb                                    ELISA                                                                            RSR, UK

 

MuSK Ab                                 RIA                                                                                 RSR, UK                                                                    

 

                                                             

 

 


Diagnostic Use and Interpretation

Muscle kinase antibodies (MuSK) will be present in approximately 50% of seronegative Myasthenia gravis patients.


Contact Information

For further information contact the laboratory, (09) 307 4949 ext 22103 or:
Associate Professor Rohan Ameratunga , Immunopathologist: Locator 93-5724,  

Dr Richard Steele , or  The LabPLUS Immunology Team



Last updated at 13:39:38 22/02/2019